SIRT2 Expression Is Higher in Uveal Melanoma than In Ocular Melanocytes
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چکیده
منابع مشابه
Status of RASSF1A in uveal melanocytes and melanoma cells.
RASSF1A gene, found at the 3p21.3 locus, is a tumor suppressor gene frequently hypermethylated in human cancers. In this study, we report that compared with melanocytes in normal choroid, RASSF1A is downregulated in uveal melanoma samples and in uveal melanoma cell lines. LOH at 3p21.3 was detected in 50% of uveal melanoma. Moreover, methylation of the RASSF1A promoter was detected in 35 of 42 ...
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متن کاملStudies of human uveal melanocytes in vitro: isolation, purification and cultivation of human uveal melanocytes.
PURPOSE To develop the methods for isolation and cultivation of human uveal melanocytes (UM) from adult donor eyes. METHODS After removal of the pigment epithelium, the uvea was pretreated in trypsin solution at 4 degrees C overnight, incubated at 37 degrees C with trypsin for 1 hr, then incubated with collagenase for 3 hr. Released cells were collected each hour during the incubation and cul...
متن کاملMelanogenesis by human uveal melanocytes in vitro.
PURPOSE To study melanogenesis by cultured human uveal melanocytes, and the relationship between melanin production by uveal melanocytes in vitro with the degree of iris pigmentation in vivo. METHODS Melanin content, melanin production, and tyrosinase activity of cultured uveal melanocytes derived from eyes of various iris color were measured at different stages of cultivation. RESULTS Cult...
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RASSF1A gene, found at the 3p21.3 locus, is a tumor suppressor gene frequently hypermethylated in human cancers. In this study, we report that compared with melanocytes in normal choroid, RASSF1A is downregulated in uveal melanoma samples and in uveal melanoma cell lines. LOH at 3p21.3was detected in 50% of uveal melanoma. Moreover, methylation of the RASSF1A promoter was detected in 35 of 42 t...
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ژورنال
عنوان ژورنال: Ocular Oncology and Pathology
سال: 2015
ISSN: 2296-4681,2296-4657
DOI: 10.1159/000439309